Tumorless Tumor Transmission

One of the first theories of cancer etiology, postulated tumors arose from disturbances in lymph flow. This theory lasted until advances in microscopy allowed a group of scientists to discover cancers were cell derived. Several studies tried to link pathogens to cancer development, but most of them lacked rigor and reproducibility. Unfortunately, this lead to a strong bias against the idea that tumors could be caused by infectious agents. In 1911, Peyton Rous challenged this bias by discovering that a chicken sarcoma could be transplanted via a cell-free tumor filtrate. However, his work was largely rejected, causing Rous to abandon his studies on the infectious agent. The agent was later identified as a retrovirus and named the Rous sarcoma virus (RVS). It was not until 1966 that Rous was awarded the Nobel Prize for the discovery of the first tumor virus.
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2124874/pdf/397.pdf
Other readings:
The History of Tumor Virology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501656/

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